EC number:6.3.5.7
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor |
| ID: | 6.3.5.7 | ||
|---|---|---|---|
| Description: | Glutaminyl-tRNA synthase (glutamine-hydrolyzing). | ||
| Alternative Name: |
Glutamyl-tRNA(Gln) amidotransferase. Glu-tRNA(Gln) amidotransferase. Glu-AdT. GatFAB. GatDE. GatCAB. | ||
| Prosite: | PDOC00948; | ||
| PDB: |
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| Cath: | 1.10.287.2340; 3.90.1300.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.5.7 |
| BRENDA Enzyme Link: | BRENDA 6.3.5.7 |
| KEGG Enzyme Link: | KEGG6.3.5.7 |
| BioCyc Enzyme Link: | BioCyc 6.3.5.7 |
| ExPASy Enzyme Link: | ExPASy6.3.5.7 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.5.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.5.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.5.7 |
| IntEnz Enzyme Link: | IntEnz 6.3.5.7 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.5.7 |
| RHEA:17521 | ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]-[C;H0;+0:6](=[*:7])-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14].[OH2;+0:15]>>[*:5]-[C;H0;+0:6](=[*:7])-[NH2;+0:4].[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:15].[*:14]-[OH;+0:13].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Glutamyl-tRNA(Gln) amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis. | Curnow AW, Tumbula DL, Pelaschier JT, Min B, Söll D | 1998 Oct 27 | 9789001 |
| Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. | Nagao A, Suzuki T, Katoh T, Sakaguchi Y, Suzuki T | 2009 Sep 22 | 19805282 |
| Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. | Frechin M, Senger B, Brayé M, Kern D, Martin RP, Becker HD | 2009 May 1 | 19417106 |
| Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. | Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY | 2008 Oct | 18667535 |
| Mechanistic studies of reaction coupling in Glu-tRNAGln amidotransferase. | Horiuchi KY, Harpel MR, Shen L, Luo Y, Rogers KC, Copeland RA | 2001 May 29 | 11371208 |
| Aminoacyl-tRNA synthesis. | Ibba M, Soll D | 2000 | 10966471 |