EC Tree |
6. Ligases |
6.3 Forming carbon-nitrogen bonds |
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor |
ID: | 6.3.5.9 |
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Description: | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing). |
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 6.3.5.9 |
BRENDA Enzyme Link: | BRENDA 6.3.5.9 |
KEGG Enzyme Link: | KEGG6.3.5.9 |
BioCyc Enzyme Link: | BioCyc 6.3.5.9 |
ExPASy Enzyme Link: | ExPASy6.3.5.9 |
EC2PDB Enzyme Link: | EC2PDB 6.3.5.9 |
ExplorEnz Enzyme Link: | ExplorEnz 6.3.5.9 |
PRIAM enzyme-specific profiles Link: | PRIAM 6.3.5.9 |
IntEnz Enzyme Link: | IntEnz 6.3.5.9 |
MEDLINE Enzyme Link: | MEDLINE 6.3.5.9 |
RHEA:12544 | 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate |
RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]-[C;H0;+0:6](=[*:7])-[NH2;+0:8].([*:9]-[C;H0;+0:10](=[*:11])-[OH;+0:12].[*:13]-[C;H0;+0:14](=[*:15])-[OH;+0:16]).[*:17]=[P;H0;+0:18](-[*:19])(-[*:20])-[O;H0;+0:21]-[*:22].[OH2;+0:23]>>([*:9]-[C;H0;+0:10](=[*:11])-[NH2;+0:4].[*:13]-[C;H0;+0:14](=[*:15])-[NH2;+0:8]).[*:5]-[C;H0;+0:6](=[*:7])-[OH;+0:12].[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:23].[*:22]-[OH;+0:21].[*:17]=[P;H0;+0:18](-[*:19])(-[*:20])-[OH;+0:16] |
Reaction | ![]() |
Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans. | Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F | 1990 Nov | 2172209 |
The biosynthesis of adenosylcobalamin (vitamin B12). | Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | 2002 Aug | 12195810 |