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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

ID:	6.3.5.9
Description:	Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing).

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UniProtKB Enzyme Link:	UniProtKB 6.3.5.9
BRENDA Enzyme Link:	BRENDA 6.3.5.9
KEGG Enzyme Link:	KEGG6.3.5.9
BioCyc Enzyme Link:	BioCyc 6.3.5.9
ExPASy Enzyme Link:	ExPASy6.3.5.9
EC2PDB Enzyme Link:	EC2PDB 6.3.5.9
ExplorEnz Enzyme Link:	ExplorEnz 6.3.5.9
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.5.9
IntEnz Enzyme Link:	IntEnz 6.3.5.9
MEDLINE Enzyme Link:	MEDLINE 6.3.5.9

RHEA:12544	2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
RULE(radius=1)	[:1]-[C;H0;+0:2](=[:3])-[NH2;+0:4].[:5]-[C;H0;+0:6](=[:7])-[NH2;+0:8].([:9]-[C;H0;+0:10](=[:11])-[OH;+0:12].[:13]-[C;H0;+0:14](=[:15])-[OH;+0:16]).[:17]=[P;H0;+0:18](-[:19])(-[:20])-[O;H0;+0:21]-[:22].[OH2;+0:23]>>([:9]-[C;H0;+0:10](=[:11])-[NH2;+0:4].[:13]-[C;H0;+0:14](=[:15])-[NH2;+0:8]).[:5]-[C;H0;+0:6](=[:7])-[OH;+0:12].[:1]-[C;H0;+0:2](=[:3])-[OH;+0:23].[:22]-[OH;+0:21].[:17]=[P;H0;+0:18](-[:19])(-[:20])-[OH;+0:16]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans.	Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F	1990 Nov	2172209
The biosynthesis of adenosylcobalamin (vitamin B12).	Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC	2002 Aug	12195810