Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
ID:6.3.5.9
Description:Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing).

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.5.9
BRENDA Enzyme Link: BRENDA 6.3.5.9
KEGG Enzyme Link: KEGG6.3.5.9
BioCyc Enzyme Link: BioCyc 6.3.5.9
ExPASy Enzyme Link: ExPASy6.3.5.9
EC2PDB Enzyme Link: EC2PDB 6.3.5.9
ExplorEnz Enzyme Link: ExplorEnz 6.3.5.9
PRIAM enzyme-specific profiles Link: PRIAM 6.3.5.9
IntEnz Enzyme Link: IntEnz 6.3.5.9
MEDLINE Enzyme Link: MEDLINE 6.3.5.9
MSA:

6.3.5.9;

Phylogenetic Tree:

6.3.5.9;

Uniprot:
M-CSA:
RHEA:12544 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]-[C;H0;+0:6](=[*:7])-[NH2;+0:8].([*:9]-[C;H0;+0:10](=[*:11])-[OH;+0:12].[*:13]-[C;H0;+0:14](=[*:15])-[OH;+0:16]).[*:17]=[P;H0;+0:18](-[*:19])(-[*:20])-[O;H0;+0:21]-[*:22].[OH2;+0:23]>>([*:9]-[C;H0;+0:10](=[*:11])-[NH2;+0:4].[*:13]-[C;H0;+0:14](=[*:15])-[NH2;+0:8]).[*:5]-[C;H0;+0:6](=[*:7])-[OH;+0:12].[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:23].[*:22]-[OH;+0:21].[*:17]=[P;H0;+0:18](-[*:19])(-[*:20])-[OH;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans.Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F1990 Nov2172209
The biosynthesis of adenosylcobalamin (vitamin B12).Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC2002 Aug12195810