EC number:6.4.1.1
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.4 Forming carbon-carbon bonds |
| 6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date) |
| ID: | 6.4.1.1 | ||
|---|---|---|---|
| Description: | Pyruvate carboxylase. | ||
| Alternative Name: |
Pyruvic carboxylase. | ||
| Prosite: | PDOC50991; PDOC50979; PDOC50975; PDOC00676; PDOC00167; | ||
| PDB: |
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| Cath: | 1.10.10.2790; 1.10.10.60; 1.10.287.160; 1.10.287.1600; 1.10.472.90; 3.10.600.10; 3.20.20.70; 3.30.1490.20; 3.30.470.130; 3.30.470.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.4.1.1 |
| BRENDA Enzyme Link: | BRENDA 6.4.1.1 |
| KEGG Enzyme Link: | KEGG6.4.1.1 |
| BioCyc Enzyme Link: | BioCyc 6.4.1.1 |
| ExPASy Enzyme Link: | ExPASy6.4.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 6.4.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.4.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.4.1.1 |
| IntEnz Enzyme Link: | IntEnz 6.4.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 6.4.1.1 |
| RHEA:20844 | ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[CH2;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure and the mechanism of action of pyruvate carboxylase. | Attwood PV | 1995 Mar | 7780827 |
| Induction of erythroid differentiation in Friend leukemia cells by bromodeoxyuridine. | Adesnik M, Snitkin H | 1978 Jun | 649667 |
| Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli. | Zeczycki TN, St Maurice M, Jitrapakdee S, Wallace JC, Attwood PV, Cleland WW | 2009 May 26 | 19341298 |
| Structure, mechanism and regulation of pyruvate carboxylase. | Jitrapakdee S, St Maurice M, Rayment I, Cleland WW, Wallace JC, Attwood PV | 2008 Aug 1 | 18613815 |
| Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme. | Adina-Zada A, Jitrapakdee S, Surinya KH, McIldowie MJ, Piggott MJ, Cleland WW, Wallace JC, Attwood PV | 2008 | 18272421 |