EC number:6.4.1.2

Enzyme

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EC Tree
     6. Ligases
        6.4 Forming carbon-carbon bonds
            6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
ID:6.4.1.2
Description:Acetyl-CoA carboxylase.
Prosite: PDOC50980; PDOC50979; PDOC00676; PDOC00167;
PDB:
PDBScop
Cath: 1.10.510.10; 1.10.8.10; 3.30.1490.20; 3.30.1490.460; 3.30.200.20; 3.30.310.80; 3.30.470.20; 3.90.1770.10; 3.90.226.10; 2.40.460.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.4.1.2
BRENDA Enzyme Link: BRENDA 6.4.1.2
KEGG Enzyme Link: KEGG6.4.1.2
BioCyc Enzyme Link: BioCyc 6.4.1.2
ExPASy Enzyme Link: ExPASy6.4.1.2
EC2PDB Enzyme Link: EC2PDB 6.4.1.2
ExplorEnz Enzyme Link: ExplorEnz 6.4.1.2
PRIAM enzyme-specific profiles Link: PRIAM 6.4.1.2
IntEnz Enzyme Link: IntEnz 6.4.1.2
MEDLINE Enzyme Link: MEDLINE 6.4.1.2

EC number:6.4.1.2

MSA:

6.4.1.2;
Phylogenetic Tree:

6.4.1.2;
Uniprot:
M-CSA:
RHEA:11308 acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate
RULE(radius=1) [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[CH2;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosis.Daniel J, Oh TJ, Lee CM, Kolattukudy PE2007 Feb17114269
Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv.Oh TJ, Daniel J, Kim HJ, Sirakova TD, Kolattukudy PE2006 Feb 1716354663