EC number:6.4.1.3

Enzyme

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EC Tree
     6. Ligases
        6.4 Forming carbon-carbon bonds
            6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
ID:6.4.1.3
Description:Propionyl-CoA carboxylase.
Alternative Name: PCCase.
Prosite: PDOC50980; PDOC50979; PDOC50975; PDOC00676; PDOC00167;
PDB:
PDBScop
Cath: 3.30.1490.20; 3.30.470.20; 3.30.700.30; 3.90.226.10; 2.40.50.100; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.4.1.3
BRENDA Enzyme Link: BRENDA 6.4.1.3
KEGG Enzyme Link: KEGG6.4.1.3
BioCyc Enzyme Link: BioCyc 6.4.1.3
ExPASy Enzyme Link: ExPASy6.4.1.3
EC2PDB Enzyme Link: EC2PDB 6.4.1.3
ExplorEnz Enzyme Link: ExplorEnz 6.4.1.3
PRIAM enzyme-specific profiles Link: PRIAM 6.4.1.3
IntEnz Enzyme Link: IntEnz 6.4.1.3
MEDLINE Enzyme Link: MEDLINE 6.4.1.3

EC number:6.4.1.3

MSA:

6.4.1.3;
Phylogenetic Tree:

6.4.1.3;
Uniprot:
M-CSA:
RHEA:23720 ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[*:6])-[OH;+0:7].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[O;H0;+0:12]-[*:13]>>[*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:5](=[*:4])-[*:6].[*:13]-[OH;+0:12].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC2006 Feb 2816492739