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6. Ligases

6.4 Forming carbon-carbon bonds

6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

ID:

6.4.1.4

Description:

Methylcrotonoyl-CoA carboxylase.

Alternative Name:

Methylcrotonyl-CoA carboxylase.
Beta-methylcrotonyl-CoA carboxylase.

Prosite:

PDOC50980; PDOC50979; PDOC50975; PDOC00167;

PDB:

PDB	Scop

Cath:

2.40.50.100;

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UniProtKB Enzyme Link:	UniProtKB 6.4.1.4
BRENDA Enzyme Link:	BRENDA 6.4.1.4
KEGG Enzyme Link:	KEGG6.4.1.4
BioCyc Enzyme Link:	BioCyc 6.4.1.4
ExPASy Enzyme Link:	ExPASy6.4.1.4
EC2PDB Enzyme Link:	EC2PDB 6.4.1.4
ExplorEnz Enzyme Link:	ExplorEnz 6.4.1.4
PRIAM enzyme-specific profiles Link:	PRIAM 6.4.1.4
IntEnz Enzyme Link:	IntEnz 6.4.1.4
MEDLINE Enzyme Link:	MEDLINE 6.4.1.4

RHEA:13589	3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA
RULE(radius=1)	[:1]-[CH;+0:2]=[C;H0;+0:3](-[:4])-[CH3;+0:5].[:6]=[C;H0;+0:7](-[:8])-[OH;+0:9].[:10]=[P;H0;+0:11](-[:12])(-[:13])-[O;H0;+0:14]-[:15]>>[:1]-[CH2;+0:2]-[C;H0;+0:3](-[:4])=[CH;+0:5]-[C;H0;+0:7](=[:6])-[:8].[:15]-[OH;+0:14].[:10]=[P;H0;+0:11](-[:12])(-[:13])-[OH;+0:9]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Purification and characterization of 3-methylcrotonyl-coenzyme-A carboxylase from leaves of Zea mays.	Diez TA, Wurtele ES, Nikolau BJ	1994 Apr	8161223
Expression, purification, characterization of human 3-methylcrotonyl-CoA carboxylase (MCCC).	Chu CH, Cheng D	2007 Jun	17360195
Purification and Characterization of 3-Methylcrotonyl-Coenzyme A Carboxylase from Higher Plant Mitochondria.	Alban C, Baldet P, Axiotis S, Douce R	1993 Jul	12231881