EC number:6.4.1.8

Enzyme

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EC Tree
     6. Ligases
        6.4 Forming carbon-carbon bonds
            6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
ID:6.4.1.8
Description:Acetophenone carboxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.4.1.8
BRENDA Enzyme Link: BRENDA 6.4.1.8
KEGG Enzyme Link: KEGG6.4.1.8
BioCyc Enzyme Link: BioCyc 6.4.1.8
ExPASy Enzyme Link: ExPASy6.4.1.8
EC2PDB Enzyme Link: EC2PDB 6.4.1.8
ExplorEnz Enzyme Link: ExplorEnz 6.4.1.8
PRIAM enzyme-specific profiles Link: PRIAM 6.4.1.8
IntEnz Enzyme Link: IntEnz 6.4.1.8
MEDLINE Enzyme Link: MEDLINE 6.4.1.8

EC number:6.4.1.8

MSA:

6.4.1.8;
Phylogenetic Tree:

6.4.1.8;
Uniprot:
M-CSA:
RHEA:28647 acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate
RULE(radius=1) [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12].[*:13]=[P;H0;+0:14](-[*:15])(-[*:16])-[O;H0;+0:17]-[*:18].[OH2;+0:19]>>[*:1]-[CH2;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:18]-[OH;+0:17].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:19].[*:13]=[P;H0;+0:14](-[*:15])(-[*:16])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
ATP-dependent carboxylation of acetophenone by a novel type of carboxylase.Jobst B, Schühle K, Linne U, Heider J2010 Mar20047908