EC number:6.5.1.4

Enzyme

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     6. Ligases
        6.5 Forming phosphoric-ester bonds
            6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
ID:6.5.1.4
Description:RNA 3'-terminal-phosphate cyclase (ATP).
Alternative Name: RNA-3'-phosphate cyclase.
RNA cyclase.
Prosite: PDOC00989;
PDB:
PDBScop
5JPQ 8048715; 8053076; 8024774; 8037153; 8063659; 8063660; 8048437; 8053217; 8044901; 8048393; 8050331; 8052770; 8052771; 8052772; 8063659; 8063660; 8048564; 8053166; 8050307; 8052972; 8052973; 8052974; 8045078; 8052733; 8052734; 8052735; 8024774; 8037153;
5TZS 8045077; 8052736; 8052737; 8052738; 8048708; 8053083; 8021104; 8033484; 8044896; 8048385; 8050323; 8052758; 8052759; 8052760; 8021104; 8033484; 8024774; 8037153; 8024774; 8037153; 8048555; 8053173;
3KGD 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394;
1QMI 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394;
3TV1 8023378; 8032016; 8035758; 8044394; 8023378; 8032016; 8035758; 8044394;
 » show all
Cath: 3.30.360.20; 3.65.10.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.5.1.4
BRENDA Enzyme Link: BRENDA 6.5.1.4
KEGG Enzyme Link: KEGG6.5.1.4
BioCyc Enzyme Link: BioCyc 6.5.1.4
ExPASy Enzyme Link: ExPASy6.5.1.4
EC2PDB Enzyme Link: EC2PDB 6.5.1.4
ExplorEnz Enzyme Link: ExplorEnz 6.5.1.4
PRIAM enzyme-specific profiles Link: PRIAM 6.5.1.4
IntEnz Enzyme Link: IntEnz 6.5.1.4
MEDLINE Enzyme Link: MEDLINE 6.5.1.4

EC number:6.5.1.4

MSA:

6.5.1.4;
Phylogenetic Tree:

6.5.1.4;
Uniprot:
M-CSA:
RHEA:23976 (RNA)-3'-(3'-phospho-ribonucleoside) + ATP = (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + AMP + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].([*:7]-[OH;+0:8].[*:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[OH;+0:13])>>[*:1]-[OH;+0:2].[*:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[O;H0;+0:8]-[*:7].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:13]
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References

TitleAuthorsDatePubMed ID
RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract.Filipowicz W, Konarska M, Gross HJ, Shatkin AJ1983 Mar 116828385
The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives.Reinberg D, Arenas J, Hurwitz J1985 May 252581947
Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis.Chakravarty AK, Smith P, Shuman S2011 Dec 2722167800