EC number:6.5.1.5

Enzyme

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     6. Ligases
        6.5 Forming phosphoric-ester bonds
            6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
ID:6.5.1.5
Description:RNA 3'-terminal-phosphate cyclase (GTP).
Alternative Name: RNA-3'-phosphate cyclase (GTP).
Cath: 3.30.360.20; 3.65.10.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.5.1.5
BRENDA Enzyme Link: BRENDA 6.5.1.5
KEGG Enzyme Link: KEGG6.5.1.5
BioCyc Enzyme Link: BioCyc 6.5.1.5
ExPASy Enzyme Link: ExPASy6.5.1.5
EC2PDB Enzyme Link: EC2PDB 6.5.1.5
ExplorEnz Enzyme Link: ExplorEnz 6.5.1.5
PRIAM enzyme-specific profiles Link: PRIAM 6.5.1.5
IntEnz Enzyme Link: IntEnz 6.5.1.5
MEDLINE Enzyme Link: MEDLINE 6.5.1.5

EC number:6.5.1.5

MSA:

6.5.1.5;
Phylogenetic Tree:

6.5.1.5;
Uniprot:
M-CSA:
RHEA:13969 (RNA)-3'-(3'-phospho-ribonucleoside) + GTP = (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + diphosphate + GMP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].([*:7]-[OH;+0:8].[*:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[OH;+0:13])>>[*:1]-[OH;+0:2].[*:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[O;H0;+0:8]-[*:7].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:13]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
GTP-dependent RNA 3'-terminal phosphate cyclase from the hyperthermophilic archaeon Pyrococcus furiosus.Sato A, Soga T, Igarashi K, Takesue K, Tomita M, Kanai A2011 Dec22074260