EC number:6.6.1.2
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.6 Forming nitrogen-D-metal bonds |
| 6.6.1 Forming coordination complexes |
| ID: | 6.6.1.2 |
|---|---|
| Description: | Cobaltochelatase. |
| Alternative Name: |
Hydrogenobyrinic acid a,c-diamide cobaltochelatase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.6.1.2 |
| BRENDA Enzyme Link: | BRENDA 6.6.1.2 |
| KEGG Enzyme Link: | KEGG6.6.1.2 |
| BioCyc Enzyme Link: | BioCyc 6.6.1.2 |
| ExPASy Enzyme Link: | ExPASy6.6.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 6.6.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.6.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.6.1.2 |
| IntEnz Enzyme Link: | IntEnz 6.6.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 6.6.1.2 |
| RHEA:15341 | ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3]2-[*:4]-[*:5]-[C;H0;+0:6](=[N;H0;+0:7]-2)-[CH;+0:8]=[C;H0;+0:9]2-[*:10]-[*:11]-[C;H0;+0:12](=[N;H0;+0:13]-2)-[C;H0;+0:14](-[*:15])=[C;H0;+0:16](-[*:17])-[NH;+0:18]-[*:19]-[*:20]-[N;H0;+0:21]=[C;H0;+0:22]-1-[*:23].[*:24]=[P;H0;+0:25](-[*:26])(-[*:27])-[O;H0;+0:28]-[*:29].[Co+2;H0:30].[OH2;+0:31]>>[*:1]-[C;H0;+0:2]1=[C;H0;+0:22](-[*:23])-[N;H0;+0:21]2-[*:20]-[*:19]-[N+;H0:18]3=[C;H0;+0:16](-[*:17])-[C;H0;+0:14](-[*:15])=[C;H0;+0:12]4-[*:11]-[*:10]-[C;H0;+0:9]5=[N+;H0:13]-4-[Co-2;H0:30]-3-2-[N+;H0:7]2=[C;H0;+0:3]-1-[*:4]-[*:5]-[C;H0;+0:6]-2=[CH;+0:8]-5.[*:29]-[OH;+0:28].[*:24]=[P;H0;+0:25](-[*:26])(-[*:27])-[OH;+0:31] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans. | Debussche L, Couder M, Thibaut D, Cameron B, Crouzet J, Blanche F | 1992 Nov | 1429466 |
| The biosynthesis of adenosylcobalamin (vitamin B12). | Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | 2002 Aug | 12195810 |