Enzyme

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EC Tree
     7. Translocases
        7.1 Catalysing the translocation of hydrons
            7.1.1 Linked to oxidoreductase reactions
ID:7.1.1.1
Description:Proton-translocating NAD(P)(+) transhydrogenase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 7.1.1.1
BRENDA Enzyme Link: BRENDA 7.1.1.1
KEGG Enzyme Link: KEGG7.1.1.1
BioCyc Enzyme Link: BioCyc 7.1.1.1
ExPASy Enzyme Link: ExPASy7.1.1.1
EC2PDB Enzyme Link: EC2PDB 7.1.1.1
ExplorEnz Enzyme Link: ExplorEnz 7.1.1.1
PRIAM enzyme-specific profiles Link: PRIAM 7.1.1.1
IntEnz Enzyme Link: IntEnz 7.1.1.1
MEDLINE Enzyme Link: MEDLINE 7.1.1.1
MSA:

7.1.1.1;

Phylogenetic Tree:

7.1.1.1;

Uniprot:
M-CSA:
RHEA:47992 H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Involvement of histidine-91 of the beta subunit in proton translocation by the pyridine nucleotide transhydrogenase of Escherichia coli.Glavas NA, Hou C, Bragg PD1995 Jun 137779816
Purification and properties of reconstitutively active nicotinamide nucleotide transhydrogenase of Escherichia coli.Clarke DM, Bragg PD1985 Jun 183891338
Cloning and expression of the transhydrogenase gene of Escherichia coli.Clarke DM, Bragg PD1985 Apr3884596
Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJ, Metherell LA2012 May 2722634753
X-ray structure of domain I of the proton-pumping membrane protein transhydrogenase from Escherichia coli.Johansson T, Oswald C, Pedersen A, Törnroth S, Okvist M, Karlsson BG, Rydström J, Krengel U2005 Sep 1616083909
The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli.Sauer U, Canonaco F, Heri S, Perrenoud A, Fischer E2004 Feb 2014660605
Proton translocating nicotinamide nucleotide transhydrogenase from E. coli. Mechanism of action deduced from its structural and catalytic properties.Bizouarn T, Fjellström O, Meuller J, Axelsson M, Bergkvist A, Johansson C, Göran Karlsson B, Rydström J2000 Apr 2110773166
The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria.White SA, Peake SJ, McSweeney S, Leonard G, Cotton NP, Jackson JB2000 Jan 1510673423