EC number:7.2.2.12
Enzyme
Download| EC Tree |
| 7. Translocases |
| 7.2 Catalysing the translocation of inorganic cations |
| 7.2.2 Linked to the hydrolysis of a nucleoside triphosphate |
| ID: | 7.2.2.12 | ||
|---|---|---|---|
| Description: | P-type Zn(2+) transporter. | ||
| Alternative Name: |
Zn(2+)-exporting ATPase. Zinc-translocating P-type ATPase. P(1B)-type ATPase. | ||
| Prosite: | PDOC00139; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 7.2.2.12 |
| BRENDA Enzyme Link: | BRENDA 7.2.2.12 |
| KEGG Enzyme Link: | KEGG7.2.2.12 |
| BioCyc Enzyme Link: | BioCyc 7.2.2.12 |
| ExPASy Enzyme Link: | ExPASy7.2.2.12 |
| EC2PDB Enzyme Link: | EC2PDB 7.2.2.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 7.2.2.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 7.2.2.12 |
| IntEnz Enzyme Link: | IntEnz 7.2.2.12 |
| MEDLINE Enzyme Link: | MEDLINE 7.2.2.12 |
| RHEA:20621 | ATP(in) + H2O(in) + Zn(2+)(in) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(out) |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pb(II)-translocating P-type ATPases. | Rensing C, Sun Y, Mitra B, Rosen BP | 1998 Dec 4 | 9830000 |
| The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase. | Rensing C, Mitra B, Rosen BP | 1997 Dec 23 | 9405611 |
| Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase. | Beard SJ, Hashim R, Membrillo-Hernández J, Hughes MN, Poole RK | 1997 Sep | 9364914 |
| The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels. | Mills RF, Francini A, Ferreira da Rocha PS, Baccarini PJ, Aylett M, Krijger GC, Williams LE | 2005 Jan 31 | 15670847 |
| Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis. | Eren E, Argüello JM | 2004 Nov | 15475410 |