EC number:7.4.2.1
Enzyme
Download| EC Tree |
| 7. Translocases |
| 7.4 Catalysing the translocation of amino acids and peptides |
| 7.4.2 Linked to the hydrolysis of a nucleoside triphosphate |
| ID: | 7.4.2.1 | ||
|---|---|---|---|
| Description: | ABC-type polar-amino-acid transporter. | ||
| Alternative Name: |
Polar-amino-acid-transporting ATPase. Histidine permease. | ||
| Prosite: | PDOC00185; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 7.4.2.1 |
| BRENDA Enzyme Link: | BRENDA 7.4.2.1 |
| KEGG Enzyme Link: | KEGG7.4.2.1 |
| BioCyc Enzyme Link: | BioCyc 7.4.2.1 |
| ExPASy Enzyme Link: | ExPASy7.4.2.1 |
| EC2PDB Enzyme Link: | EC2PDB 7.4.2.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 7.4.2.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 7.4.2.1 |
| IntEnz Enzyme Link: | IntEnz 7.4.2.1 |
| MEDLINE Enzyme Link: | MEDLINE 7.4.2.1 |
| RHEA:14673 | a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. | Saier MH Jr | 1998 | 9889977 |
| The Escherichia coli ATP-binding cassette (ABC) proteins. | Linton KJ, Higgins CF | 1998 Apr | 9593292 |
| Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity. | Nikaido K, Liu PQ, Ames GF | 1997 Oct 31 | 9346917 |
| Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity. | Walshaw DL, Lowthorpe S, East A, Poole PS | 1997 Sep 8 | 9315727 |
| Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. | Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr | 1995 May | 7569321 |
| RHEA:29879 | ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:29883 | ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:29887 | ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |