CURCUMIN
Relevant Data
Food Additives Approved by European Union:
General Information
| Synonyms: | CI NATURAL YELLOW 3, DIFERULOYLMETHANE, KURKUM, TURMERIC YELLOW |
| Chemical Names: | I. 1,7-bis-(4-HYDROXY-3-METHOXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE; II. 1-(4-HYDROXYPHENYL)-7-(4-HYDROXY-3-METHOXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE; III. 1,7-bis (4-HYDROXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE |
| CAS number: | 458-37-7 |
| INS: | 100(i) |
| Functional Class: |
Food Additives COLOUR |
From apps.who.int
Evaluations
| Evaluation year: | 2003 |
| ADI: | 0-3 mg/kg bw |
| Meeting: | 44 |
| Specs Code: | S |
| Report: | TRS 922-JECFA 61/18 |
| Tox Monograph: | FAS 52-JECFA 61/55 |
| Specification: | COMPENDIUM ADDENDUM 11/FNP 52 Add.11/29; FAO JECFA Monographs 1 vol.1/417 |
From apps.who.int
GSFA Provisions for CURCUMIN
| Number | Food Category | Max Level | Notes |
|---|---|---|---|
| 01.1.4 | Flavoured fluid milk drinks |
150 mg/kg | Note 402,Note 52 |
| 12.5 | Soups and broths |
50 mg/kg | Note 99 |
From www.fao.org
Targets
- General Function:
- Zinc ion binding
- Specific Function:
- Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
- Gene Name:
- PPARG
- Uniprot ID:
- P37231
- Molecular Weight:
- 57619.58 Da
- General Function:
- Zinc ion binding
- Specific Function:
- Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
- Gene Name:
- VDR
- Uniprot ID:
- P11473
- Molecular Weight:
- 48288.64 Da
- General Function:
- Organic anion transmembrane transporter activity
- Specific Function:
- Acts as a multispecific organic anion pump which can transport nucleotide analogs.
- Gene Name:
- ABCC5
- Uniprot ID:
- O15440
- Molecular Weight:
- 160658.8 Da
- General Function:
- Prostaglandin-e2 9-reductase activity
- Specific Function:
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
- Gene Name:
- CBR1
- Uniprot ID:
- P16152
- Molecular Weight:
- 30374.73 Da
- General Function:
- S-nitrosoglutathione binding
- Specific Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
- Gene Name:
- GSTP1
- Uniprot ID:
- P09211
- Molecular Weight:
- 23355.625 Da
From T3DB