EC number:1.14.15.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.15.4 | ||
|---|---|---|---|
| Description: | Steroid 11-beta-monooxygenase. | ||
| Alternative Name: |
Steroid 11-beta/18-hydroxylase. Steroid 11-beta-hydroxylase. Cytochrome p450 XIB1. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
|
||
| Cath: | 1.10.630.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.15.4 |
| BRENDA Enzyme Link: | BRENDA 1.14.15.4 |
| KEGG Enzyme Link: | KEGG1.14.15.4 |
| BioCyc Enzyme Link: | BioCyc 1.14.15.4 |
| ExPASy Enzyme Link: | ExPASy1.14.15.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.15.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.15.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.15.4 |
| IntEnz Enzyme Link: | IntEnz 1.14.15.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.15.4 |
EC number:1.14.15.4
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:15629 | a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:7]-[Fe;H0;+0:8]-[*:9].[H+;H0:10].[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:12].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[Fe+;H0:8]-[*:9].[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis. | Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P | 1986 Mar 15 | 3485096 |
| Structural insights into aldosterone synthase substrate specificity and targeted inhibition. | Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW | 2013 Feb | 23322723 |
| Studies on the nature of steroid 11-beta hydroxylation. | TOMKINS GM, MICHAEL PJ, CURRAN JF | 1957 Mar | 13426185 |
| The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation. | GRANT JK, BROWNIE AC | 1955 Nov | 13276417 |
| On the mechanism of the C11 beta-hydroxylation of steroids. | HAYANO M, DORFMAN RI | 1954 Nov | 13211659 |