Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
ID:1.14.19.70
Description:Mycocyclosin synthase.
Alternative Name: CYP121.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.19.70
BRENDA Enzyme Link: BRENDA 1.14.19.70
KEGG Enzyme Link: KEGG1.14.19.70
BioCyc Enzyme Link: BioCyc 1.14.19.70
ExPASy Enzyme Link: ExPASy1.14.19.70
EC2PDB Enzyme Link: EC2PDB 1.14.19.70
ExplorEnz Enzyme Link: ExplorEnz 1.14.19.70
PRIAM enzyme-specific profiles Link: PRIAM 1.14.19.70
IntEnz Enzyme Link: IntEnz 1.14.19.70
MEDLINE Enzyme Link: MEDLINE 1.14.19.70
MSA:

1.14.19.70;

Phylogenetic Tree:

1.14.19.70;

Uniprot:
M-CSA:
RHEA:35547 cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.([*:9]:[cH;+0:10]:[*:11].[*:12]:[cH;+0:13]:[*:14]).[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[c;H0;+0:13](:[*:12]):[*:14].[OH2;+0:16].[OH2;+0:17]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courçon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M2009 May 519416919