| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.70 |
|---|---|
| Description: | Mycocyclosin synthase. |
| Alternative Name: |
CYP121. |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| UniProtKB Enzyme Link: | UniProtKB 1.14.19.70 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.70 |
| KEGG Enzyme Link: | KEGG1.14.19.70 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.70 |
| ExPASy Enzyme Link: | ExPASy1.14.19.70 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.70 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.70 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.70 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.70 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.70 |
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35547 | cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.([*:9]:[cH;+0:10]:[*:11].[*:12]:[cH;+0:13]:[*:14]).[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[c;H0;+0:13](:[*:12]):[*:14].[OH2;+0:16].[OH2;+0:17] |
| Reaction | ![]() |
| Core-to-Core | |
| Core-to-Core |
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. | Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courçon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M | 2009 May 5 | 19416919 |