EC number:1.14.99.37

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.99 Miscellaneous
ID:1.14.99.37
Description:Taxadiene 5-alpha-hydroxylase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.99.37
BRENDA Enzyme Link: BRENDA 1.14.99.37
KEGG Enzyme Link: KEGG1.14.99.37
BioCyc Enzyme Link: BioCyc 1.14.99.37
ExPASy Enzyme Link: ExPASy1.14.99.37
EC2PDB Enzyme Link: EC2PDB 1.14.99.37
ExplorEnz Enzyme Link: ExplorEnz 1.14.99.37
PRIAM enzyme-specific profiles Link: PRIAM 1.14.99.37
IntEnz Enzyme Link: IntEnz 1.14.99.37
MEDLINE Enzyme Link: MEDLINE 1.14.99.37

EC number:1.14.99.37

MSA:

1.14.99.37;
Phylogenetic Tree:

1.14.99.37;
Uniprot:
M-CSA:
RHEA:14049 AH2 + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol
RULE(radius=1) [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[CH3;+0:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2](-[OH;+0:6])-[C;H0;+0:3](-[*:4])=[CH2;+0:5].[OH2;+0:7]
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References

TitleAuthorsDatePubMed ID
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis.Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R1996 Jun8807878
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.Rontein D, Onillon S, Herbette G, Lesot A, Werck-Reichhart D, Sallaud C, Tissier A2008 Mar 718167342
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.Jennewein S, Long RM, Williams RM, Croteau R2004 Mar15123267