EC number:1.5.1.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| PDB |
4QJZ;
4IXG;
4IXF;
4IXE;
4G8Z;
4CD2;
3TD8;
3NZC;
3NZB;
3NZA;
3NZ9;
3NZ6;
3CD2;
2FZI;
2CD2;
1VJ3;
1S3Y;
1LY4;
1LY3;
1KLK;
1E26;
1DYR;
1DAJ;
1CD2;
6DE4;
6DAV;
4KFJ;
4KEB;
4KD7;
4KBN;
4KAK;
2W3M;
2W3B;
2W3A;
2C2T;
2C2S;
1DHF;
6A7E;
6A7C;
5HVE;
5HVB;
5HUI;
5HT5;
5HT4;
5HSU;
5HSR;
5HQZ;
5HQY;
5HPB;
4QJC;
4QHV;
4M6L;
4M6K;
4M6J;
4G95;
4DDR;
3S7A;
3S3V;
3OAF;
3NZD;
3NXY;
3NXX;
3NXV;
3NXT;
3NXR;
3NXO;
3NU0;
3NTZ;
3N0H;
3L3R;
3GYF;
3GI2;
3GHW;
3GHV;
3GHC;
3FS6;
3F91;
3F8Z;
3F8Y;
3EIG;
1YHO;
1U72;
1U71;
1S3W;
1S3V;
1S3U;
1PDB;
1PD9;
1PD8;
1OHK;
1OHJ;
1MVT;
1MVS;
1KMV;
1KMS;
1HFR;
1HFQ;
1HFP;
1DRF;
1DLS;
1DLR;
1BOZ;
1JUV;
4HOF;
4HOE;
4H97;
4H96;
4H95;
3QLW;
3QLS;
3QLR;
1M7A;
1M79;
1M78;
1IA4;
1IA3;
1IA2;
1IA1;
1AOE;
1AI9;
8DFR;
1DR7;
1DR6;
1DR5;
1DR4;
1DR3;
1DR2;
1DR1;
1VDR;
2JYB;
2ITH;
1D1G;
1CZ3;
6DDS;
6DDP;
5JA3;
4M2X;
4KNE;
4KM2;
4KM0;
4KLX;
6DDW;
5UJF;
5U27;
5U26;
4KL9;
2CIG;
1DG7;
1DG5;
1DF7;
3DFR;
2LF1;
2L28;
2HQP;
2HM9;
1LUD;
1DIU;
1DIS;
1BZF;
1AO8;
5UIO;
5UJX;
5UIP;
5EAJ;
5E8Q;
4X5G;
4X5F;
4GH8;
4EJ1;
4EIZ;
4DFR;
3OCH;
3DRC;
2INQ;
2DRC;
2D0K;
1TDR;
1RE7;
1RD7;
1RB3;
1RB2;
1JOL;
1DYJ;
1DYI;
1DYH;
1DRB;
1DRA;
1DHJ;
1DHI;
1DDS;
1DDR;
7DFR;
6MTH;
6MT8;
6MR9;
6DFR;
6CQA;
5Z6M;
5Z6L;
5Z6K;
5Z6J;
5Z6F;
5W3Q;
5UII;
5UIH;
5DFR;
5CCC;
5CC9;
4X5J;
4X5I;
4X5H;
4PDJ;
4NX7;
4NX6;
4KJL;
4KJK;
4KJJ;
4I1N;
4I13;
4FHB;
4EIG;
3R33;
3QYO;
3QYL;
3QL3;
3KFY;
3K74;
3DAU;
2ANQ;
2ANO;
1RX9;
1RX8;
1RX7;
1RX6;
1RX5;
1RX4;
1RX3;
1RX2;
1RX1;
1RH3;
1RG7;
1RF7;
1RC4;
1RA9;
1RA8;
1RA3;
1RA2;
1RA1;
1JOM;
1DRH;
1DRE;
3DGA;
1J3K;
1J3J;
3DG8;
1J3I;
6N1T;
6N1S;
6E4E;
6AOI;
6AOH;
6AOG;
5T0L;
5JG0;
5IST;
5ISQ;
5ISP;
5HF2;
5HF0;
4XEC;
4XE6;
4LEK;
4LAH;
4LAG;
4LAE;
4KYA;
4KY4;
4FGH;
4FGG;
4EIL;
4ECK;
3SRW;
3SRU;
3SRS;
3SRR;
3SRQ;
3SR5;
3SQY;
3SH2;
3SGY;
3RG9;
3QFX;
3M09;
3M08;
3LG4;
3K47;
3K45;
3IX9;
3IRO;
3IRN;
3IRM;
3INV;
3I8A;
3HBB;
3FYW;
3FYV;
3FY9;
3FY8;
3FRF;
3FRE;
3FRD;
3FRB;
3FRA;
3D84;
3D80;
3CLB;
3CL9;
2W9T;
2W9S;
2W9H;
2W9G;
2H2Q;
2FZJ;
2FZH;
2DHF;
2BLC;
2BLB;
2BLA;
2BL9;
1U70;
1DG8;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.3 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.3 |
| KEGG Enzyme Link: | KEGG1.5.1.3 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.3 |
| ExPASy Enzyme Link: | ExPASy1.5.1.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.3 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.3 |
| RHEA:15009 | (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[N;H0;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. | Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J | 1982 Nov 25 | 6815178 |
| Studies on dihydrofolic reductase. I. Purification and properties of dihydrofolic reductase from chicken liver. | Kaufman BT, Gardiner RC | 1966 Mar 25 | 4379915 |
| Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli. | Young IG, Gibson F | 1969 May 6 | 4306838 |