EC number:1.5.1.33
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.33 | ||
|---|---|---|---|
| Description: | Pteridine reductase. | ||
| Alternative Name: |
PTR1. Pteridine reductase 1. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.33 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.33 |
| KEGG Enzyme Link: | KEGG1.5.1.33 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.33 |
| ExPASy Enzyme Link: | ExPASy1.5.1.33 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.33 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.33 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.33 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.33 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.33 |
| RHEA:19509 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[CH2;+0:3]-[NH;+0:4]-[*:5]:[*:6]-[NH;+0:7]-1.[*:8]-[c;H0;+0:9]1:[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:[n+;H0:13](-[*:14]):[cH;+0:15]:1.[*:16]-[n+;H0:17]1:[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:[c;H0;+0:21](-[*:22]):[cH;+0:23]:1>>[*:8]-[C;H0;+0:9]1=[CH;+0:15]-[N;H0;+0:13](-[*:14])-[CH;+0:12]=[CH;+0:11]-[CH2;+0:10]-1.[*:16]-[N;H0;+0:17]1-[CH;+0:18]=[CH;+0:19]-[CH2;+0:20]-[C;H0;+0:21](-[*:22])=[CH;+0:23]-1.[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n;H0;+0:4]:[*:5]:[*:6]:[n;H0;+0:7]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence. | Luba J, Nare B, Liang PH, Anderson KS, Beverley SM, Hardy LW | 1998 Mar 24 | 9521731 |
| Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. | Schüttelkopf AW, Hardy LW, Beverley SM, Hunter WN | 2005 Sep 9 | 16055151 |
| Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani. | Kumar P, Kothari H, Singh N | 2004 Dec | 15555938 |
| Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. | Gourley DG, Schüttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN | 2001 Jun | 11373620 |