EC number:4.1.3.44
| ID: | 4.1.3.44 |
|---|---|
| Description: | tRNA 4-demethylwyosine synthase (AdoMet-dependent). |
| Cath: | 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.44 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.44 |
| KEGG Enzyme Link: | KEGG4.1.3.44 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.44 |
| ExPASy Enzyme Link: | ExPASy4.1.3.44 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.44 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.44 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.44 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.44 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.44 |
| RHEA:36347 | N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[S+;H0:3](-[*:4])-[*:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[C;H0;+0:9](-[*:10])=[O;H0;+0:11].[CH3;+0:12]-[*:13]:[*:14]-[NH2;+0:15]>>[*:1]-[CH3;+0:2].[*:4]-[S;H0;+0:3]-[*:5].[*:10]-[c;H0;+0:9]1:[cH;+0:12]:[*:13]:[*:14]:[nH;+0:15]:1.[*:6]=[C;H0;+0:7]=[O;H0;+0:8].[OH2;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 4-Demethylwyosine synthase from Pyrococcus abyssi is a radical-S-adenosyl-L-methionine enzyme with an additional [4Fe-4S](+2) cluster that interacts with the pyruvate co-substrate. | Perche-Letuvée P, Kathirvelu V, Berggren G, Clemancey M, Latour JM, Maurel V, Douki T, Armengaud J, Mulliez E, Fontecave M, Garcia-Serres R, Gambarelli S, Atta M | 2012 Nov 30 | 23043105 |
| Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine. | Young AP, Bandarian V | 2011 Dec 13 | 22026549 |