EC number:2.1.1.45
3D structure
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4ISK;
1KZJ;
2A9W;
6NNR;
6CDZ;
4GEV;
3BHL;
3B5B;
2VF0;
2TSC;
2KCE;
2G8X;
2BBQ;
1ZPR;
1TSD;
1TLS;
1TLC;
1TDU;
1SYN;
1NCE;
1KZI;
1KCE;
1JUT;
1JTU;
1JTQ;
1JG0;
1FWM;
1F4G;
1F4F;
1F4C;
1DNA;
1DDU;
1BQ1;
1AXW;
1AN5;
1AIQ;
3TMS;
3BHR;
3BFI;
3B9H;
2VET;
2FTQ;
2FTO;
2FTN;
1TSN;
1TRG;
1TJS;
1FFL;
1F4E;
1F4B;
1EVG;
1EV5;
1BQ2;
1BJG;
1BID;
1BDU;
1AOB;
1AJM;
4TMS;
3IK1;
3IK0;
3IJZ;
3C0A;
3C06;
3BYX;
3BNZ;
2TDM;
2TDD;
2G8D;
2G8A;
2G89;
2G86;
1VZE;
1VZD;
1VZC;
1VZB;
1VZA;
1TVW;
1TVV;
1TVU;
1TSZ;
1TSY;
1TSX;
1TSW;
1TSV;
1TSM;
1TSL;
1THY;
1TDC;
1TDB;
1TDA;
1NJE;
1NJD;
1NJC;
1NJB;
1NJA;
1LCE;
1LCB;
1LCA;
1JMI;
1JMH;
1JMG;
1JMF;
1BP6;
1BP0;
1BO8;
1BO7;
5X69;
5X66;
5X5Q;
5X5D;
5X5A;
5HS3;
2RDA;
3OB7;
3HB8;
3H9K;
4UP1;
4H1I;
3GG5;
3EJL;
1JUJ;
1JU6;
1HVY;
6QXH;
6QXG;
5X67;
2RD8;
1I00;
1HZW;
5X4Y;
5X4X;
5X4W;
4GYH;
3GH2;
3GH0;
3EHI;
3EF9;
3EDW;
3ED7;
3EAW;
1HW4;
2TSR;
1RTS;
1TIS;
1BKO;
1BSP;
1BSF;
1BKP;
1B02;
1F28;
1CI7;
3DGA;
1J3K;
1J3J;
3DG8;
1J3I;
6QXS;
6N1T;
6N1S;
6F6Z;
6AOI;
6AOH;
6AOG;
5WRN;
5T0L;
5J7W;
5H3A;
5H39;
5H38;
5FCT;
4XSE;
4XSD;
4XSC;
4O7U;
4LRR;
4KYA;
4KY4;
4H0U;
4H0R;
4FQS;
4FOX;
4FOG;
4FOA;
4EZ8;
4EIN;
4EIL;
4ECK;
4EB4;
4E5O;
4DQ1;
3UWL;
3QJ7;
3KGB;
3IX6;
3IRO;
3IRN;
3IRM;
3INV;
3IHI;
3HBB;
3CLB;
3CL9;
3BZ0;
2H2Q;
2AAZ;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.45 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.45 |
| KEGG Enzyme Link: | KEGG2.1.1.45 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.45 |
| ExPASy Enzyme Link: | ExPASy2.1.1.45 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.45 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.45 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.45 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.45 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.45 |
| RHEA:12104 | (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]-[CH;+0:4](-[*:5])-[N;H0;+0:6](-[*:7])-[CH2;+0:8]-1.[*:9]:[cH;+0:10]:[*:11]>>[*:1]-[NH;+0:2]-[*:3]-[C;H0;+0:4](-[*:5])=[N;H0;+0:6]-[*:7].[*:9]:[c;H0;+0:10](:[*:11])-[CH3;+0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography. | Slavík K, Slavíková V | 1980 | 6990200 |
| Thymidylate synthetase purified to homogeneity from human leukemic cells. | Lockshin A, Moran RG, Danenberg PV | 1979 Feb | 34155 |
| The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli. | WAHBA AJ, FRIEDKIN M | 1962 Dec | 13998281 |