EC number:3.1.1.84
| ID: | 3.1.1.84 | ||
|---|---|---|---|
| Description: | Cocaine esterase. | ||
| Alternative Name: |
Human carboxylesterase 2. | ||
| Prosite: | PDOC00112; | ||
| PDB: |
|
||
| Cath: | 1.10.3020.10; 3.40.50.1820; 2.60.120.260; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.84 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.84 |
| KEGG Enzyme Link: | KEGG3.1.1.84 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.84 |
| ExPASy Enzyme Link: | ExPASy3.1.1.84 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.84 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.84 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.84 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.84 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.84 |
| RHEA:27506 | cocaine + H2O = benzoate + ecgonine methyl ester + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. | Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF | 1997 Jun 6 | 9169443 |
| Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. | Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG | 2009 Feb | 18987161 |
| Identification of a cocaine esterase in a strain of Pseudomonas maltophilia. | Britt AJ, Bruce NC, Lowe CR | 1992 Apr | 1551831 |
| Crystal structure of a bacterial cocaine esterase. | Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA | 2002 Jan | 11742345 |
| Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. | Bresler MM, Rosser SJ, Basran A, Bruce NC | 2000 Mar | 10698749 |