EC number:3.5.1.15
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.15 |
|---|---|
| Description: | Aspartoacylase. |
| Alternative Name: |
Aminoacylase II. |
| Cath: | 3.30.70.1640; 3.30.70.360; 3.40.630.10; 2.20.25.160; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.15 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.15 |
| KEGG Enzyme Link: | KEGG3.5.1.15 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.15 |
| ExPASy Enzyme Link: | ExPASy3.5.1.15 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.15 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.15 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.15 |
| RHEA:10872 | H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Clinically Distinct Phenotypes of Canavan Disease Correlate with Residual Aspartoacylase Enzyme Activity. | Mendes MI, Smith DE, Pop A, Lennertz P, Fernandez Ojeda MR, Kanhai WA, van Dooren SJ, Anikster Y, Barić I, Boelen C, Campistol J, de Boer L, Kariminejad A, Kayserili H, Roubertie A, Verbruggen KT, Vianey-Saban C, Williams M, Salomons GS | 2017 May | 28101991 |
| New T530C mutation in the aspartoacylase gene caused Canavan disease with no correlation between severity and N-acetylaspartate excretion. | Di Pietro V, Cavallari U, Amorini AM, Lazzarino G, Longo S, Poggiani C, Cavalli P, Tavazzi B | 2013 Dec | 24036223 |
| Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease. | Herga S, Berrin JG, Perrier J, Puigserver A, Giardina T | 2006 Oct 30 | 17027983 |
| Aspartoacylase is a regulated nuclear-cytoplasmic enzyme. | Hershfield JR, Madhavarao CN, Moffett JR, Benjamins JA, Garbern JY, Namboodiri A | 2006 Oct | 16935940 |
| Specificity of amino acid acylases. | BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP | 1952 Jan | 14927637 |