EC number:4.3.2.10
| ID: | 4.3.2.10 |
|---|---|
| Description: | Imidazole glycerol-phosphate synthase. |
| Alternative Name: |
IGP synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.3.2.10 |
| BRENDA Enzyme Link: | BRENDA 4.3.2.10 |
| KEGG Enzyme Link: | KEGG4.3.2.10 |
| BioCyc Enzyme Link: | BioCyc 4.3.2.10 |
| ExPASy Enzyme Link: | ExPASy4.3.2.10 |
| EC2PDB Enzyme Link: | EC2PDB 4.3.2.10 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.3.2.10 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.3.2.10 |
| IntEnz Enzyme Link: | IntEnz 4.3.2.10 |
| MEDLINE Enzyme Link: | MEDLINE 4.3.2.10 |
| RHEA:24793 | 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[nH;+0:6]:[cH;+0:7]:[n;H0;+0:8]:1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12].[H+;H0:13]>>[*:3]-[C;H0;+0:4](=[O;H0;+0:12])-[CH2;+0:5]-[N;H0;+0:6]=[CH;+0:7]-[NH;+0:2]-[*:1].[*:9]=[C;H0;+0:10](-[*:11])-[NH2;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. | Douangamath A, Walker M, Beismann-Driemeyer S, Vega-Fernandez MC, Sterner R, Wilmanns M | 2002 Feb | 11839304 |
| Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase. | Myers RS, Amaro RE, Luthey-Schulten ZA, Davisson VJ | 2005 Sep 13 | 16142895 |
| Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme. | Chaudhuri BN, Lange SC, Myers RS, Davisson VJ, Smith JL | 2003 Jun 17 | 12795595 |
| Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex. | Beismann-Driemeyer S, Sterner R | 2001 Jun 8 | 11264293 |