EC number:5.4.3.5
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.3 Transferring amino groups |
| ID: | 5.4.3.5 |
|---|---|
| Description: | D-ornithine 4,5-aminomutase. |
| Alternative Name: |
D-ornithine aminomutase. D-alpha-ornithine 5,4-aminomutase. |
| Cath: | 1.10.8.10; 1.10.8.100; 1.10.8.1000; 1.20.5.40; 1.20.5.4020; 3.20.20.440; 3.30.30.60; 3.40.50.280; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.3.5 |
| BRENDA Enzyme Link: | BRENDA 5.4.3.5 |
| KEGG Enzyme Link: | KEGG5.4.3.5 |
| BioCyc Enzyme Link: | BioCyc 5.4.3.5 |
| ExPASy Enzyme Link: | ExPASy5.4.3.5 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.3.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.3.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.3.5 |
| IntEnz Enzyme Link: | IntEnz 5.4.3.5 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.3.5 |
| RHEA:14893 | D-ornithine = (2R,4S)-2,4-diaminopentanoate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[NH2;+0:4]>>[*:1]-[CH;+0:2](-[CH3;+0:3])-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5,4-aminomutase. | Somack R, Costilow RN | 1973 Jul 3 | 4711468 |
| Large-scale domain motions and pyridoxal-5'-phosphate assisted radical catalysis in coenzyme B12-dependent aminomutases. | Maity AN, Chen YH, Ke SC | 2014 Feb 20 | 24562332 |
| Mutagenesis of a conserved glutamate reveals the contribution of electrostatic energy to adenosylcobalamin co-C bond homolysis in ornithine 4,5-aminomutase and methylmalonyl-CoA mutase. | Makins C, Pickering AV, Mariani C, Wolthers KR | 2013 Feb 5 | 23311430 |
| Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study. | Pang J, Li X, Morokuma K, Scrutton NS, Sutcliffe MJ | 2012 Feb 1 | 22239442 |
| Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase. | Makins C, Miros FN, Scrutton NS, Wolthers KR | 2012 Feb | 21899873 |
| Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-ornithine aminomutase from Clostridium sticklandii. | Chen HP, Wu SH, Lin YL, Chen CM, Tsay SS | 2001 Nov 30 | 11577113 |