EC number:6.3.1.9
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases) |
| ID: | 6.3.1.9 | ||
|---|---|---|---|
| Description: | Trypanothione synthase. | ||
| Alternative Name: |
TSR synthetase. | ||
| Prosite: | PDOC50975; | ||
| PDB: |
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| Cath: | 3.30.1490.330; 3.90.1720.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.1.9 |
| BRENDA Enzyme Link: | BRENDA 6.3.1.9 |
| KEGG Enzyme Link: | KEGG6.3.1.9 |
| BioCyc Enzyme Link: | BioCyc 6.3.1.9 |
| ExPASy Enzyme Link: | ExPASy6.3.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.1.9 |
| IntEnz Enzyme Link: | IntEnz 6.3.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.1.9 |
| RHEA:21532 | ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities. | Fyfe PK, Oza SL, Fairlamb AH, Hunter WN | 2008 Jun 20 | 18420578 |
| Trypanothione synthesis in crithidia revisited. | Comini M, Menge U, Wissing J, Flohé L | 2005 Feb 25 | 15537651 |
| Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. | Smith K, Nadeau K, Bradley M, Walsh C, Fairlamb AH | 1992 Jul | 1304372 |
| A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. | Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH | 2002 Sep 27 | 12121990 |
| RHEA:21272 | ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |